This thing came with a X1900 and it's beginning to show age. Will the new card with the new Mac Pros work in this bitch? Better yet, could I Crossfire these two?
Not sure it would work in an '06 Mac Pro. Besides not being PCI-E 2.0, the '06s also have 32-bit EFI (which caused a flap when '06 owners wanted to install the then-new 8800GT in their rigs). I believe you can use a 32-bit compliant card in a 64-bit EFI machine, but not the other way 'round.
That being said, I wonder what the 4870 costs stand-alone, as I think I'd like to slide one into my '08 Mac Pro. I also wonder if the 4870 X2 would work with a Mac-compatible BIOS flashed onto it...