I was unaware of this issue, and thought I'd pass it along. I just installed an X-Fi Fatality, and noticed under heavy HD access, lots of pops, static, etc. Others are having the same problems. In common, most are using Adaptec XX160/320 SCSI cards/nForce4 boards. I can duplicate it. Play music/sounds while searching, all kinds of popping/static, etc. I've tried different PCI latencies, slots, etc. Not cool for a $300 soundcard.
http://forums.creative.com/creativelabs/board/message?board.id=soundblaster&message.id=30036
http://forums.creative.com/creativelabs/board/message?board.id=soundblaster&message.id=30036