Case design help!

[EXreaction]

Hey everyone...I was thinking of building a comp case out of plexi, and I was going to design it around the Lian-Li case...with the psu, and hdds on the bottom etc...well, I was wondering...would it be better to have the mobo upside down like it is on this case? Lian Li
Or should I have it with the mobo turned the normal way?