My MS 3.0 mouse doesnt pick up on start up of Win

[Pcrepairman]

My MS 3.0 mouse doesnt pick up on start up of Win
My system specs

P4 2.4C GHz (@ 3.3 GHZ)
Asus P4C800 E- DELUXE
OCZ Pc4200 cl 2.5 512MB
Stock Intel Heat Sink AS 5
Asus P4C800 E Deluxe
Antec True Power 480 watt
ATI Radeon 9600XT=@ 540/330
WD RAPTOR 2X36.6 (RAID-0)
WD 5400rpm 2x40gb (RAID 1)

I have a Microsoft Ms 3.0 mouse, Sometimes when i restart my computer it just does not work. The lights on the bottom of the mouse go on during the post but when It gets to windows it just does not work. It does sometimes(It is now) but when i restart it sometimes does not and needs a Hard boot to get it back sometimes 3 or 4 times. I don't like replugging it in and out of my usb ports because i don't want to mess anything up. I also tried my brothers Ms 3.0 and I had the same problem. I don't think it is the mouse