Yeah I think as we said in the past, mini ITX is the new mATX. I think manufacturers need to wake up and smell the coffee. 60cm-high towers triple-GTX295 (or whatever) with 1200W PSU will/should become a thing of the past. The new standard is mATX, and the new SFF is mini ITX, especially with 1-chip chipsets.
My pet peeve now is graphics cards manufacturers who seem to want to produce bigger and more power-hungry cards. Why did all of a sudden AMD produce a 5870 slightly longer than 10.5in? Until now their 4870/4890 were much shorter. And what do we hear from nVidia? They want to produce a 2-billion transistor GPU. How are they going to cool that? 13" triple slot cards? I mean what the hell. Anything bigger than a 5770 (ok then, a 5850) is ridiculous. I just sold my GTX 260 and when I took it out of my case I realised I had forgotten how big it is. Ridiculous (I know I said it already, but I like it).
Profit margin, I guess.
New case, new power supply and new motherboard mean new production lines. That means more investment.
With current economy, I doubt it that business will change its product unless there is huge demand for ITX and MicroATX computers.