Old thread revival, but I just found this interesting post and although it relates to SSDs, it claims that the B5/181 "Program_Fail_Cnt_Total" SMART attribute - in a Crucial SSD - is an indication of 4K mapping (in)effectiveness, it's the number of unaligned reads and writes.
Could this also be true for Samsung Advanced Format HDDs as well? This would explain why some users have such rapidly increasing counts (unaligned data) without any obvious reliability problems.